PropertyValue
?:definition
  • A population of closely human leukocyte antigen (HLA)-matched, off-the-shelf (OTS), donor-derived cytotoxic T lymphocytes (CTLs) that are specifically reactive towards six viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human herpesvirus 6 (HHV6; HHV-6), human polyomavirus type I (BKV) and human polyomavirus type II (JC virus; JCV), with potential antiviral activity. Upon infusion into allogeneic hematopoietic stem cell transplant (HSCT) recipients and immunocompromised patients, allogeneic multi-virus-specific CTLs ALVR105 provides virus-specific cellular immunity and causes specific anti-viral effects against active viral infections. This may prevent EBV, CMV, AdV, HHV6, BKV and JCV reactivation and infection, and inhibits viral-associated diseases.
?:hasCUIAnnotation
?:hasGeneratedBy
?:type

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/C5417937_NCI>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/C5417937_NCI>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all