PropertyValue
?:definition
  • A fusion protein of leukocyte-associated immunoglobulin (Ig)-like receptor (LAIR)-2, a high-affinity collagen receptor, with potential immunomodulatory and antineoplastic activities. Upon administration, LAIR-2 fusion protein NC410 binds to the ligand collagen of LAIR-1 (CD305), thereby blocking the binding of LAIR-1 to its ligand collagen and inhibiting LAIR-1-mediated immune suppression. This may result in enhanced T-cell and dendritic cell (DC) activities, and cytotoxic T-lymphocyte (CTL) and anti-tumor immune responses. LAIR-1, a collagen-receptor and an inhibitory immune receptor belonging to the Ig superfamily, is expressed on many peripheral blood mononuclear cells (PBMC) including T-cells and DCs.
?:hasCUIAnnotation
?:hasGeneratedBy
?:type

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/C5418001_NCI>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/C5418001_NCI>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all