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  • A preparation of purified human immunoglobulin G (hIgG), neutralizing polyclonal antibodies directed against the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and derived from the plasma of immunized transchromosomic (Tc) bovines, that can potentially be used for immunization and protection against Coronavirus disease 2019 (COVID-19). Upon administration of anti-SARS-CoV-2 polyclonal antibodies SAB-185, the antibodies specifically target and bind to the SARS-CoV-2 S protein, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. S protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.
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