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  • An otic ointment formulation of the broad-spectrum aminoglycoside antibiotic gentamicin sulfate, the synthetic adrenocorticoid betamethasone valerate and the broad-spectrum antifungal agent clotrimazole, with antibacterial, anti-inflammatory, and antifungal activities. Upon otic administration, gentamicin sulfate/betamethasone valerate/clotrimazole otic ointment inhibits bacterial protein synthesis and replication, inhibits fungal sterols biosynthesis which leads to fungal cell leakage and fungal cell lysis, and inhibits the inflammatory response by preventing phospholipid release, inhibiting eosinophil activity, and decreasing pro-inflammatory cytokine production.
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