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  • An oncolytic viral agent containing the oncolytic, live-attenuated, replication-competent strain of the avian paramyxovirus Newcastle disease virus (NDV) that has been engineered to include a transgene encoding the human pro-inflammatory cytokine interleukin-12 (IL-12), with potential antineoplastic and immunostimulating activities. Upon administration, recombinant NDV-encoding IL-12 MEDI9253 specifically infects and replicates in cancer cells. This may result in a direct cytotoxic effect involving the lysis of tumor cells via apoptotic mechanisms and may eventually lead to an inhibition of cancer cell proliferation. The production and secretion of IL-12 may potentiate and strengthen the anti-tumor immune response and activates the immune system by promoting the activation of natural killer cells (NK cells), inducing secretion of interferon-gamma and promoting cytotoxic T-cell responses against tumor cells.
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