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  • A radioconjugate consisting of tabituximab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against Frizzled-10 (FZD10; CD350), conjugated to the diethylenetriaminepentaacetic acid (DTPA) chelator derivative barzuxetan and labeled with the gamma-emitting isotope indium In 111, which may be used to detect FZD10-expressing tumor cells upon gamma scintigraphy. Upon administration of indium In 111 tabituximab barzuxetan, tabituximab targets and binds to FZD10 expressed on tumor cells. This allows for visualization of FZD10-expressing tumor cells upon gamma scintigraphy. FZD10, a member of the Frizzled family of G protein-coupled receptors, is one of the components in the Wnt/beta-catenin signaling pathway that plays key roles in embryogenesis and cancer growth.
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