PropertyValue
?:definition
  • A human immunoglobulin G4 (IgG4) monoclonal antibody directed against the immunosuppressive protein galectin-9, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-galectin-9 monoclonal antibody LYT-200 targets, binds to and blocks galectin-9 on tumor cells which prevents galectin-9-mediated signaling. This may abrogate activation of immunosuppressive signaling pathways in the tumor microenvironment (TME) and may activate a cytotoxic T-lymphocyte (CTL)-mediated immune response against the galectin-9-expressing tumor cells. Galectin-9, overexpressed on a variety of tumor cells, plays a key role in cancer cell proliferation and evasion of immune responses. Its expression is correlated with decreased patient survival.
?:hasCUIAnnotation
?:hasGeneratedBy
?:type

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/C5447746_NCI>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/C5447746_NCI>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all