a43bcqei

Property	Value
?:abstract	Study Objectives: Point-of-care ultrasound (POCUS) may be used as a valuable tool for risk stratification of patients with COVID-19 as its characteristic POCUS findings have recently been described In the present study, we aim to define the prognostic value of cardiopulmonary POCUS in patients with COVID-19 Here, we correlate POCUS findings with patient-centered outcomes such as need for intubation, intensive care unit (ICU) admission, and mortality Methods: 125 patients presenting to an urban ED in Tehran, Iran with symptoms concerning for COVID-19 were prospectively enrolled between March 8 and April 4, 2020 Participants underwent pulmonary POCUS following a 12-zone PLUS-Co protocol, and cardiac POCUS using a standardized 4-view protocol ED physicians performed scans and provided real-time scan interpretations, images were reassessed by a second, blinded reviewer for quality control and inter-rater reliability For pulmonary POCUS, each lung zone was individually assessed for pleural line irregularities, alveolar interstitial syndrome (eg, B-lines), and subpleural consolidations (SCs), then scored using a 4-point measure Zone scores were aggregated to generate a cumulative lung involvement score per patient Cardiac POCUS was assessed for ejection fraction, right ventricular function, pericardial effusion and inferior vena cava collapsibility Clinical course and outcome variables were collected via retrospective chart review Descriptive statistics were performed to evaluate the distribution and frequency of positive POCUS findings and their correlation with patient outcomes including ICU admission, mechanical ventilation, inpatient length of stay, and mortality Results: COVID-19-positive patients demonstrated higher bilateral lung involvement scores than COVID-19-negative patients overall (p< 001, r2= 667), with significantly increased B-lines (p adj= 000000804), pulmonary consolidations (p adj= 0304), pleural thickening (p adj= 000000742), and SCs (p adj= 000000500) Increased B-lines were most pronounced in the AS, AX, and PLAPS distributions (p adj= 0086, 0012, 0024 respectively), whereas pleural thickening was noted in all lung regions (AS, AI, PS, PI, AX, PLAPS;p adj= 0182, 0014, 0375, 0328, 0003, 0), and subpleural consolidation were most prominent in AS, AX, and PLAPS (p adj= 0312, 0398, 0324) In performing regression analysis no single positive POCUS finding was significantly correlated with patient outcomes inducing mortality, and need for intubation, nor was lung involvement score as a whole Conclusion: In patients with COVID-19, regionalized POCUS findings and aggregate lung involvement scores were not predictive of patient outcomes including mortality Despite this, cardiopulmonary POCUS may still provide valuable diagnostic and risk stratification data in patients with suspected COVID-19 Further investigation of the clinical applications of a cardiopulmonary POCUS disease profile in COVID-19 is needed [Formula presented]
is ?:annotates of	<https://research.tib.eu/covid-19/entity/a43bcqei_hasAnnotation_C1457887>
?:creator	<https://research.tib.eu/covid-19/entity/Shokoohi%2C_H.%3B_Chahardoli%2C_M.%3B_Loesche%2C_M._A.%3B_Sabbaghan_Kermani%2C_S.%3B_Schulwolf%2C_S.%3B_Abdollahzade_Manqoutaei%2C_S.%3B_Tofighi%2C_R.%3B_Yadegari%2C_S.%3B_Duggan%2C_N.>
?:journal	Annals_of_Emergency_Medicine
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/a43bcqei_HAS_C0264545_PREDISPOSES_C5203670>
?:source	WHO
?:title	155 Using Point-of-Care Ultrasound to Predict Clinical Outcomes in Patients With COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#898403
?:year	2020

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Value

?:abstract

Study Objectives: Point-of-care ultrasound (POCUS) may be used as a valuable tool for risk stratification of patients with COVID-19 as its characteristic POCUS findings have recently been described In the present study, we aim to define the prognostic value of cardiopulmonary POCUS in patients with COVID-19 Here, we correlate POCUS findings with patient-centered outcomes such as need for intubation, intensive care unit (ICU) admission, and mortality Methods: 125 patients presenting to an urban ED in Tehran, Iran with symptoms concerning for COVID-19 were prospectively enrolled between March 8 and April 4, 2020 Participants underwent pulmonary POCUS following a 12-zone PLUS-Co protocol, and cardiac POCUS using a standardized 4-view protocol ED physicians performed scans and provided real-time scan interpretations, images were reassessed by a second, blinded reviewer for quality control and inter-rater reliability For pulmonary POCUS, each lung zone was individually assessed for pleural line irregularities, alveolar interstitial syndrome (eg, B-lines), and subpleural consolidations (SCs), then scored using a 4-point measure Zone scores were aggregated to generate a cumulative lung involvement score per patient Cardiac POCUS was assessed for ejection fraction, right ventricular function, pericardial effusion and inferior vena cava collapsibility Clinical course and outcome variables were collected via retrospective chart review Descriptive statistics were performed to evaluate the distribution and frequency of positive POCUS findings and their correlation with patient outcomes including ICU admission, mechanical ventilation, inpatient length of stay, and mortality Results: COVID-19-positive patients demonstrated higher bilateral lung involvement scores than COVID-19-negative patients overall (p< 001, r2= 667), with significantly increased B-lines (p adj= 000000804), pulmonary consolidations (p adj= 0304), pleural thickening (p adj= 000000742), and SCs (p adj= 000000500) Increased B-lines were most pronounced in the AS, AX, and PLAPS distributions (p adj= 0086, 0012, 0024 respectively), whereas pleural thickening was noted in all lung regions (AS, AI, PS, PI, AX, PLAPS;p adj= 0182, 0014, 0375, 0328, 0003, 0), and subpleural consolidation were most prominent in AS, AX, and PLAPS (p adj= 0312, 0398, 0324) In performing regression analysis no single positive POCUS finding was significantly correlated with patient outcomes inducing mortality, and need for intubation, nor was lung involvement score as a whole Conclusion: In patients with COVID-19, regionalized POCUS findings and aggregate lung involvement scores were not predictive of patient outcomes including mortality Despite this, cardiopulmonary POCUS may still provide valuable diagnostic and risk stratification data in patients with suspected COVID-19 Further investigation of the clinical applications of a cardiopulmonary POCUS disease profile in COVID-19 is needed [Formula presented]

is ?:annotates of