PropertyValue
?:abstract
  • The article describes the rationale for inhibition of the renin-angiotensin system (RAS) pathways as specific targets in patients infected by SARS-CoV-2 in order to prevent positive feedback-loop mechanisms. Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed. In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease.
?:creator
?:doi
?:doi
  • 10.3390/cells9071704
?:journal
  • Cells
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/976238239003e85de36f23ad0e24298082e95693.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7408073.xml.json
?:pmcid
?:pmid
?:pmid
  • 32708755.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 Patients
?:type
?:year
  • 2020-07-16

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