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?:abstract
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Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2-specific CD8(+) T cells by MHC class I multimer staining and examined their phenotypes and functions in acute and convalescent COVID-19. Multimer(+) cells exhibited early differentiated effector-memory phenotypes in the early convalescent phase. The frequency of stem-like memory cells was increased among multimer(+) cells in the late convalescent phase. Cytokine secretion assays combined with MHC class I multimer staining revealed that the proportion of interferon-γ (IFN-γ)-producing cells was significantly lower among SARS-CoV-2-specific CD8(+) T cells than those specific to influenza A virus. Importantly, the proportion of IFN-γ-producing cells was higher in PD-1(+) cells than PD-1(−) cells among multimer(+) cells, indicating that PD-1-expressing, SARS-CoV-2-specific CD8(+) T cells are not exhausted, but functional. Our current findings provide information for understanding of SARS-CoV-2-specific CD8(+) T cells elicited by infection or vaccination.
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10.1016/j.immuni.2020.12.002
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document_parses/pdf_json/988e930ddd3bca5a9b5e5e9b43f51821868b5381.json; document_parses/pdf_json/5b2b845079cb25b6db46be26f14a5032b4589504.json
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document_parses/pmc_json/PMC7834198.xml.json
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PD-1-Expressing SARS-CoV-2-Specific CD8(+) T Cells Are Not Exhausted, but Functional in Patients with COVID-19
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