PropertyValue
?:abstract
  • The recovery process of COVID-19 patients is unclear. Some recovered patients complain of continued shortness of breath. Vasculopathy has been reported in COVID-19, stressing the importance of probing microstructure and function of lungs at the alveolar-capillary interface. While CT detects structural abnormalities, little is known about the impact of disease on lung function. 129Xe MRI is a technique uniquely capable of assessing ventilation, microstructure and gas exchange. Using 129Xe MRI, we found COVID-19 patients have higher ventilation defects percentage (5.9% vs 3.7%), unchanged microstructure, longer gas-blood exchange time (43.5 ms vs 32.5 ms), and reduced RBC/TP (0.279 vs 0.330) compared with healthy subjects. These findings suggest regional ventilation and alveolar airspace dimensions are relatively normal around the time of discharge, while gas-blood exchange function is diminished. This study establishes the feasibility of localized lung function measurement in COVID-19 patients. Such readouts could be useful as a supplement to structural imaging.
is ?:annotates of
?:creator
?:journal
  • Sci._Adv
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Damaged lung gas-exchange function of discharged COVID-19 patients detected by hyperpolarized 129Xe MRI
?:type
?:who_covidence_id
  • #1015574
  • #967741
?:year
  • 2020

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