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Introduction. An effective vaccine for COVID-19 is only of value if the public has confidence in taking it. There is little data on COVID-19-specific vaccine confidence or its determinants in the United States. The objective of this study was to determine public confidence in a COVID-19 vaccine. Methods. A cross-sectional survey of Pennsylvanian adults, August-October, 2020, to identify their likelihood of taking an approved, no-cost coronavirus vaccine, general vaccine acceptance, and sociodemographic traits to identify predictors of vaccine acceptance. Results. Of the 950 respondents, 55% were \'very likely\', 20% \'somewhat likely\', 14% \'unsure\', 4% \'somewhat unlikely\', and 7% \'very unlikely\' to take a coronavirus vaccine, even though 70% had taken the flu vaccine since September 2019. The strongest predictors of vaccine acceptance were trust in the system evaluating vaccines and perceptions of local COVID-19 vaccination norms. The strongest predictors of negative vaccine intentions were worries about unknown side-effects and positive attitudes toward natural infection. Sociodemographic factors, political views, and religiosity did not predict vaccine intentions. Conclusions. Fewer adults intend to take a coronavirus vaccine than currently take the flu vaccine. To overcome coronavirus vaccine hesitancy, information campaigns to reinforce positive predictors and overcome negative predictors are indicated.
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