PropertyValue
?:abstract
  • Coronavirus disease 2019 (COVID-19) causes a wide range of symptoms, including several unexpected symptoms such as loss of taste, skin changes, and eye problems. We recently observed patients with documented COVID-19 develop de novo severe genitourinary symptoms, most notably urinary frequency of ≥ 13 episodes/24 hours and nocturia ≥ 4 episodes/night. We call these associated urinary symptoms COVID-19 associate cystitis (CAC). COVID-19 severity is associated with inflammation. We collected urine samples from COVID-19 patients, including patients with CAC, and found elevation of proinflammatory cytokines also in the urine. It has been previously shown that patients with urinary incontinence and ulcerative interstitial cystitis/bladder pain syndrome have elevated urinary inflammatory cytokines compared to normal controls. We therefore hypothesize that CAC, with presentation of de novo severe urinary symptoms, can occur in COVID-19 and is caused by increased inflammatory cytokines that are released into the urine and/or expressed in the bladder. The most important implications of our hypothesis are: 1) Physician caring for COVID-19 patients should be aware of COVID-19 associate cystitis (CAC); 2) De novo urinary symptoms should be included in the symptom complex associated with COVID-19; and 3) COVID-19 inflammation may result in bladder dysfunction.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.mehy.2020.110375
?:doi
?:journal
  • Med_Hypotheses
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/8badb2c9d3220693cbda741640ac6b6b01783c83.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7644255.xml.json
?:pmcid
?:pmid
?:pmid
  • 33213997.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • COVID-19 Inflammation Results in Urine Cytokine Elevation and Causes COVID-19 Associated Cystitis (CAC)
?:type
?:year
  • 2020-11-05

Metadata

Anon_0  
expand all