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BACKGROUND: Critical shortages of personal protective equipment especially N95 respirators during the COVID- 19 pandemic continues to be a source of concern Novel methods of N95 filtering facepiece respirator decontamination that can be scaled-up for in-hospital use can help address this concern and keep HCWs safe METHODS: A multidisciplinary pragmatic study was conducted to evaluate the use of an ultrasonic room high-level disinfection system (HLDS) that generates aerosolized peracetic acid (PAA) and hydrogen peroxide for decontamination of large numbers of N95 respirators A cycle duration that consistently achieved disinfection of N95 respirators (defined as ≥6 log10 reductions in bacteriophage MS2 and Geobacillus stearothermophilus spores inoculated onto respirators) was identified The treated masks were assessed for changes to their hydrophobicity, material structure, strap elasticity, and filtration efficiency (FE) PAA and hydrogen peroxide off-gassing from treated masks were also assessed RESULTS: The PAA room HLDS was effective for disinfection of bacteriophage MS2 and G stearothermophilus spores on respirators in a 2447 cubic feet room with aerosol deploy and dwell times of 16 and 32 minutes, respectively The total cycle time was 1 hour and 16 minutes After 5 treatment cycles, no adverse effects were detected on filtration efficiency, structural integrity, or strap elasticity There was no detectable off-gassing of PAA and hydrogen peroxide from the treated masks at 20 and 60 minutes after the disinfection cycle respectively CONCLUSION: The PAA room disinfection system provides a rapidly scalable solution for in-hospital decontamination of large numbers of N95 respirators during the COVID- 19 pandemic
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Infect_Control_Hosp_Epidemiol
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Scalable In-hospital Decontamination of N95 Filtering Facepiece Respirator with a Peracetic Acid Room Disinfection System
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