PropertyValue
?:abstract
  • We analyzed 21,676 residual specimens from Ontario, Canada collected between March-August, 2020 to investigate the effect of antibody decline on SARS-CoV-2 seroprevalence estimates. Testing specimens orthogonally using the Abbott (anti-nucleocapsid) and then the Ortho (anti-spike) assays, seroprevalence estimates ranged from 0.4%-1.4%, despite ongoing disease activity. The geometric mean concentration (GMC) of antibody-positive specimens decreased over time (p=0.015), and the GMC of antibody-negative specimens increased over time (p=0.0018). The association between the two tests decreased each month (p<0.001), suggesting anti-N antibody decline. Lowering the Abbott antibody index cut-off from 1.4 to 0.7 resulted in a 16% increase in positive specimens.
?:creator
?:doi
?:doi
  • 10.1093/infdis/jiaa796
?:journal
  • The_Journal_of_infectious_diseases
?:license
  • unk
?:pmid
?:pmid
  • 33400794.0
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • SARS-CoV-2 seroprevalence survey estimates are affected by anti-nucleocapsid antibody decline.
?:type
?:year
  • 2021-01-05

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