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?:abstract
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pBackground: COVID-19 caused by SARS-CoV-2 in December 2019 has become a pandemic/pphazard to the community health It is a respiratory difficulty causing fever, dry cough, fatigue,/ppshortness of breath, muscle aches and some instances lead to pneumonia Coronaviruses have/pplarge viral RNA Genomes and are single-stranded positive-sense RNA viruses The nsp10/nsp16/ppprotein is an important target because it is essential for the virus to replicate, the papain-like/ppprotease (Nsp3), the main protease (Nsp5), the primary RNA-dependent RNA polymerase/pp(Nsp12) are also attractive drug targets for this disease The uses of phytochemicals as/pptherapeutic agents have been increasing in recent years Some antiviral phytochemicals were/pptaken based on literature survey for this study /ppMethods: ADME parameters and drug like nature of phytochemicals were screened using/ppSwissADME web tool Three dimensional structures of targets are downloaded from Protein/ppData Bank and docked with phytochemicals & control by using software FlexX /ppResults: Morin shows significant results in ADME screening and Drug likeness prediction/ppstudies, it shows stable bonding pattern with all four targets in compare to other phytochemicals/ppand control, shows least score in docking and forms maximum number of hydrogen bonds with/ppthe active residues of the receptors /ppConclusion: Based on present observation of docking results, ADME parameters and drug like/ppnature, we suggest that morin may be a potent new drug candidate against Covid-19 /ppKeywords: COVID-19, coronavirus, drug target, phytochemicals, Drug likeness, ADME,/ppdocking, morin/p
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