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Background COVID-19-associated coagulopathy is most often characterized by elevated D-dimer, interleukin-6 and plasma fibrinogen concentration as well as hypercoagulability in thromboelastometry with increase clot firmness in EXTEM, INTEM and FIBTEM. Clinically, it strikes with a very high incidence of thrombosis, in particular in the pulmonary system, while bleeding complications are infrequent. Case Here, we describe two critically ill COVID-19 patients admitted to our intensive care unit with different thromboelastometry and biomarker patterns. One patient presents with hypercoagulability and the other patient with hypocoagulability and fibrinolysis shutdown in thromboelastometry. Pathophysiology and potential impact on treatment options are discussed. Conclusions Combinations of biomarkers and thromboelastometry results can be helpful in the future to decide which therapeutic strategy might be most appropriate in individual critically ill COVID-19 patients. This would be an important step to establish precision medicine in this high-risk patient population.
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Korean_journal_of_anesthesiology
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Hyper- and hypocoagulability in COVID-19 as assessed by thromboelastometry. Two case reports.
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