cad5qkfd

Property	Value
?:abstract	OBJECTIVES: To examine whether patients with multisystem inflammatory syndrome in children (MIS-C) demonstrated well-defined clinical features distinct from other febrile outpatients given the difficulties of seeing acute care visits during the SARS-CoV-2 pandemic and the risks associated with both over and underdiagnosis of MIS-C. STUDY DESIGN: This case-controlled study compared patients diagnosed with and treated for MIS-C at a large urban children’s hospital with patients evaluated for fever at outpatient acute care visits during the peak period of MIS-C. Symptomatology and available objective data were extracted. Comparisons were performed using t-tests with corrections for multiple comparisons, and multivariable logistic regression to obtain odds ratios. RESULTS: We identified 44 patients with MIS-C between April 16 and June 10, 2020. During the same period 181 pediatric patients were evaluated for febrile illnesses in participating outpatient clinics. MIS-C patients reported higher median Tmax (40 degrees C vs 38.9, P < .0001), and increased frequency of abdominal pain (OR 12.5, 95% CI [1.65-33.24]), neck pain (536.5, [2.23-129,029]), conjunctivitis (31.3, [4.6-212.8]), oral mucosal irritation (11.8, [1.4-99.4]), extremity swelling or rash (99.9, [5-1960]) and generalized rash (7.42, [1.6-33.2]). Patients with MIS-C demonstrated lower absolute lymphocyte (p<0.0001) and platelet counts (p<0.05) and higher C-reactive protein concentrations (p<0.001). CONCLUSIONS: Patients treated for MIS-C due to concern for potential cardiac injury show combinations of features distinct from other febrile patients seen in outpatient clinics during the same period.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/cad5qkfd_hasAnnotation_C0000737> <https://research.tib.eu/covid-19/entity/cad5qkfd_hasAnnotation_C0007859> <https://research.tib.eu/covid-19/entity/cad5qkfd_hasAnnotation_C0015230> <https://research.tib.eu/covid-19/entity/cad5qkfd_hasAnnotation_C0015967> <https://research.tib.eu/covid-19/entity/cad5qkfd_hasAnnotation_C0018805> <https://research.tib.eu/covid-19/entity/cad5qkfd_hasAnnotation_C0158369> <https://research.tib.eu/covid-19/entity/cad5qkfd_hasAnnotation_C3539957> <https://research.tib.eu/covid-19/entity/cad5qkfd_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Carlin%2C_Rebecca_F.%3B_Fischer%2C_Avital_M.%3B_Pitkowsky%2C_Zachary%3B_Abel%2C_Dori%3B_Sewell%2C_Taylor_B.%3B_Landau%2C_Erika_Grun%3B_Caddle%2C_Steve%3B_Robbins-Milne%2C_Laura%3B_Boneparth%2C_Alexis%3B_Milner%2C_Josh_D.%3B_Cheung%2C_Eva_W.%3B_Zachariah%2C_Philip%3B_Stockwell%2C_Melissa_S.%3B_Anderson%2C_Brett_R.%3B_Gorelik%2C_Mark>
?:doi	<https://research.tib.eu/covid-19/entity/10.1016/j.jpeds.2020.10.013>
?:doi	10.1016/j.jpeds.2020.10.013
?:journal	J_Pediatr
?:license	no-cc
?:pdf_json_files	document_parses/pdf_json/d567d1012de2f97e92ec1d69c29d9f9d5690adb9.json
?:pmc_json_files	document_parses/pmc_json/PMC7553071.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7553071>
?:pmid	<https://research.tib.eu/covid-19/entity/33065115.0>
?:pmid	33065115.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/d567d1012de2f97e92ec1d69c29d9f9d5690adb9>
?:source	Elsevier; Medline; PMC
?:title	Discriminating MIS-C Requiring Treatment from Common Febrile Conditions in Outpatient Settings
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-10-13

Property

Value

?:abstract

OBJECTIVES: To examine whether patients with multisystem inflammatory syndrome in children (MIS-C) demonstrated well-defined clinical features distinct from other febrile outpatients given the difficulties of seeing acute care visits during the SARS-CoV-2 pandemic and the risks associated with both over and underdiagnosis of MIS-C. STUDY DESIGN: This case-controlled study compared patients diagnosed with and treated for MIS-C at a large urban children’s hospital with patients evaluated for fever at outpatient acute care visits during the peak period of MIS-C. Symptomatology and available objective data were extracted. Comparisons were performed using t-tests with corrections for multiple comparisons, and multivariable logistic regression to obtain odds ratios. RESULTS: We identified 44 patients with MIS-C between April 16 and June 10, 2020. During the same period 181 pediatric patients were evaluated for febrile illnesses in participating outpatient clinics. MIS-C patients reported higher median Tmax (40 degrees C vs 38.9, P < .0001), and increased frequency of abdominal pain (OR 12.5, 95% CI [1.65-33.24]), neck pain (536.5, [2.23-129,029]), conjunctivitis (31.3, [4.6-212.8]), oral mucosal irritation (11.8, [1.4-99.4]), extremity swelling or rash (99.9, [5-1960]) and generalized rash (7.42, [1.6-33.2]). Patients with MIS-C demonstrated lower absolute lymphocyte (p<0.0001) and platelet counts (p<0.05) and higher C-reactive protein concentrations (p<0.001). CONCLUSIONS: Patients treated for MIS-C due to concern for potential cardiac injury show combinations of features distinct from other febrile patients seen in outpatient clinics during the same period.

is ?:annotates of