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Coronaviruses have caused three major outbreaks of infectious disease since the beginning of 21st century. Broad-spectrum strategies that can be utilized in both current and future coronavirus outbreaks and mutation-tolerant are sought after. Here we report a monoclonal antibody 3E8 targeting human angiotensin-converting enzyme 2 (ACE2) neutralized pseudo-typed coronaviruse SARS-CoV-2, SARS-CoV-2-D614G, SARS-CoV and HCoV-NL63, without affecting physiological activities of ACE2 or causing toxicity in mouse model. 3E8 also blocked live SARS-CoV-2 infection in vitro and in a mouse model of COVID-19. Cryo-EM studies revealed the binding site of 3E8 on ACE2 and identified Histone 34 of ACE2 as a critical site of anti-viral epitope. Overall, our work has provided a potential “pan” coronavirus management strategy and disclosed a “pan” anti-coronavirus epitope on human ACE2 for the first time. Summary Blocking Multiple Coronaviruses by An ACE2-Neutralizing Monoclonal Antibody
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10.1101/2020.11.11.375972
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document_parses/pdf_json/15e164caaf01a12076c6375c3f3caff01bd4408b.json
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ACE2-Targeting Monoclonal Antibody As A “Pan” Coronavirus Blocker In Vitro and In A Mouse Model
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