PropertyValue
?:abstract
  • Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detect preexisting humoral immunity SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were detectable by a flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents They were predominantly of the IgG class and targeted the S2 subunit By contrast, SARS-CoV-2 infection induced higher titers of SARS-CoV-2 S-reactive IgG antibodies, targeting both the S1 and S2 subunits, and concomitant IgM and IgA antibodies, lasting throughout the observation period Notably, SARS-CoV-2-uninfected donor sera exhibited specific neutralizing activity against SARS-CoV-2 and SARS-CoV-2 S pseudotypes Distinguishing preexisting and de novo immunity will be critical for our understanding of susceptibility to and the natural course of SARS-CoV-2 infection
is ?:annotates of
?:creator
?:journal
  • Science
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
?:type
?:who_covidence_id
  • #913669
?:year
  • 2020

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