PropertyValue
?:abstract
  • Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans. Although HIF-1 is currently being assessed in numerous clinical settings as a potential therapy for different diseases, up to date, there are no clinical studies evaluating the pharmacological modulation of this transcription factor as a possible new antiviral treatment. However, based on the available evidence, clinical trials targeting this molecule are likely to occur soon. In this review we discuss the role of HIF-1 in viral immunity, the modulation of HIF-1 by different types of viruses, as well as the effects of HIF-1 over their life cycle and the potential use of HIF-1 as a new target for the treatment of viral infections.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1080/21505594.2020.1836904
?:journal
  • Virulence
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/44b7cd4b085e32fc6e3e3091385a1f9eb6ae5cdd.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7605355.xml.json
?:pmcid
?:pmid
?:pmid
  • 33135539.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Contribution of hypoxia inducible factor-1 during viral infections
?:type
?:year
  • 2020-10-31

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