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New SARS-CoV-2 variants are constantly emerging and putting a strain on public health systems by spreading faster and potentially evading immune protection through vaccination. One of these strains is the B.1.1.7 variant that has initially been described in the UK and has subsequently spread to several countries. Monitoring the amplification of the S gene - a major hotspot for molecular evolution - by RT-PCR allows rapidly screening for such variants. This report describes the detection of sequence variants in Romania by using this strategy followed by next generation sequencing of the entire genome for confirmation and further characterization. One B.1.1.7 and three B.1.258 sequences where confirmed. Each of these strains presented additional mutations with possible impact on the replicative capacity. Conclusion: public health strategies should be devised in order to ensure molecular monitoring of SARS-CoV-2 evolution during the pandemic and allow adequate and rapid reaction.
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AIDS_research_and_human_retroviruses
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Evidence of novel SARS-CoV-2 variants circulation in Romania.
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