PropertyValue
?:abstract
  • SARS-CoV-2, a novel coronavirus causing overwhelming death and infection worldwide, has emerged as a pandemic Compared to its predecessor SARS-CoV, SARS-CoV-2 is more infective for being highly contagious and exhibiting tighter binding with host angiotensin-converting enzyme 2 (hACE-2) The entry of the virus into host cells is mediated by the interaction of its spike protein with hACE-2 Thus, a peptide that has a resemblance to hACE-2 but can overpower the spike protein-hACE-2 interaction will be a potential therapeutic to contain this virus The non-interacting residues in the receptor-binding domain of hACE-2 have been mutated to generate a library of 136 new peptides Out of this library, docking and virtual screening discover seven peptides that can exert a stronger interaction with the spike protein than hACE-2 A peptide derived from simultaneous mutation of all the non-interacting residues of hACE-2 yields two-fold stronger interaction than hACE-2 and thus turns out here to be the best peptide-inhibitor of the novel coronavirus The binding of the spike protein and the best peptide-inhibitor with hACE-2 is explored further by molecular dynamics, free energy, and principal component analysis to demonstrate its efficacy Further, the inhibition assay study with the best peptide inhibitor is in progress
is ?:annotates of
?:creator
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • ACE-2-derived Biomimetic Peptides for the Inhibition of Spike Protein of SARS-CoV-2
?:type
?:who_covidence_id
  • #362
?:year
  • 2020

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/den52en5>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/den52en5>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all