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?:abstract
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AIM: This study determined the influence of the COVID-19 pandemic on the occurrence of multisystem inflammatory syndrome in children (MIS-C) and compared the main characteristics of MIS-C and Kawasaki disease (KD). METHODS: We included patients aged up to 18 years of age who were diagnosed with MIS-C or KD in a paediatric university hospital in Paris from 1 January 2018 to 15 July 2020. Clinical, laboratory and imaging characteristics were compared and new French COVID-19 cases were correlated with MIS-C cases in our hospital. RESULTS: There were seven children with MIS-C, from six months to 12 years of age, who were all positive for the virus that causes COVID-19, and 40 virus negative children with KD. Their respective characteristics were: under five years of age (14.3% versus 85.0%), paediatric intensive care unit admission (100% versus 10.0%), abdominal pain (71.4% versus 12.5%), myocardial dysfunction (85.7% versus 5.0%), shock syndrome (85.7% versus 2.5%) and mean and standard deviation C-reactive protein (339 ±131 versus 153 ±87). These was a strong lagged correlation between the rise and fall in MIS-C patients and COVID-19 cases. CONCLUSION: The rise and fall of COVID-19 first-wave mirrored the MIS-C cases. There were important differences between MIS-C and KD.
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