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In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of diseases and potentially also play a critical role in host-pathogen interactions In light of the current SARS-CoV-2 pandemic, we here highlight the possible role of lung tissue stiffening with ageing and how this might facilitate increased SARS-CoV-2 replication through matrix-stiffness dependent epithelial-to-mesenchymal transitions of the lung epithelium This emphasizes the need for integrating material properties of tissues in drug discovery programs © 2020
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Current_Opinion_in_Solid_State_and_Materials_Science
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Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity
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