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?:abstract
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SARS-CoV-2 or COVID-19 is one of the deadly pandemics faced by the world population, which has infected 7 million and claimed the lives of 0 4 million people In spite of a few drugs available to control the pandemics, a formal vaccine is the least that the world expects under the current scenario However, the release of a vaccine is expected to come at the cost of its own time SARS-CoV-2 replicates in the host cells with the aids of the molecular machinery of a complex formed by three non-structural proteins (NSPs) viz , nsp12, nsp8, and nsp7 Recent studies reveal that among the three NSPs, nsp12 is vital for viral replication and is the target for drugs Several studies have linked the viral infection to a weaker immune system, which is quite likely to be targeted by the virus In search of such a natural compound that might increase the immunity and block the viral replication within the host, we selected C-Phycocyanin of Spirulina plantesis to study its anti-viral property in-silico Spirulina is a free-floating filamentous microalgae growing in alkaline water bodies It is a well-known source of valuable food supplements, such as proteins, vitamins, amino acids, minerals, etc In the present study, we focused on the possibility of C-Phycocyanin to inhibit the active site of nsp12, which is very much needed for viral replication Auto Dock, Auto Grid, and Discovery Studios tools reveal that C-Phycocyanin inhibits the active site of nsp12 thereby interfering with the replication of the virus itself
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