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?:abstract
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Background: The novel coronavirus (COVID-19) has quickly spread throughout the globe, affecting millions of people The World Health Organization (WHO) has recently declared this infectious disease as a pandemic At present, several clinical trials are going on to identify possible drugs for treating this infection SARS-CoV-2 M supro /suis one of the most critical drug targets for the blockage of viral replication Method: The blind molecular docking analyses of natural anthraquinones with SARS-CoV-2 M supro /suwere carried out in an online server, SWISSDOCK, which is based on EADock DSS docking software Results: Blind molecular docking studies indicated that several natural antiviral anthraquinones could prove to be effective inhibitors for SARS-CoV-2 M supro /suof COVID-19 as they bind near the active site having the catalytic dyad, HIS41 and CYS145 through non-covalent forces The anthraquinones showed less inhibitory potential as compared to the FDA approved drug, remdesivir /iConclusion: Among the natural anthraquinones , alterporriol Q could be the most potential inhibitor of SARS-CoV-2 M supro /suamong the natural anthraquinones studied here, as its ∆ G value differed from that of remdesivir only by 0 51 kcal/ mol The uses of these alternate compounds might be favorable for the treatment of the COVID-19
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