PropertyValue
?:abstract
  • Aging is generally characterized as a gradual increase in tissue damage, which is associated with senescence and chronic systemic inflammation and is evident in a variety of age-related diseases. The extent to which such tissue damage is a result of a gradual decline in immune regulation, which consequently compromises the capacity of the body to repair damages, has not been fully explored. Whereas CD4 T lymphocytes play a critical role in the orchestration of immunity, thymus involution initiates gradual changes in the CD4 T-cell landscape, which may significantly compromise tissue repair. In this review, we describe the lifespan accumulation of specific dysregulated CD4 T-cell subsets and their coevolution with systemic inflammation in the process of declined immunity and tissue repair capacity with age. Then, we discuss the process of thymus involution-which appears to be most pronounced around puberty-as a possible driver of the aging T-cell landscape. Finally, we identify individualized T cell-based early diagnostic biomarkers and therapeutic strategies for age-related diseases.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.arr.2020.101231
?:doi
?:journal
  • Ageing_research_reviews
?:license
  • cc-by
?:pmid
?:pmid
  • 33248315.0
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • Thymus involution sets the clock of declined immunity and repair with aging.
?:type
?:year
  • 2020-11-25

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