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?:abstract
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Background :Due to the reported high ability of virulence of COVID_19 in recent months, several studies have been conducted to discover and introduce COVID_19 antiviral drugs The results of numerous studies have shown that protease inhibitors and compounds, which make uthe major part of plant derivatives, especially terpenoids, can therefore be very effective in controlling virus-induced infection The aim of this research is the bioinformatical study of COVID_19 inhibition by terpenoids of plant origin Materials and Methods : This is a descriptive-analytic study In the present study , the structure of terpene comounds and COVID_19 protease was received from the databases such as PubChem and Protein Data Bank (PDB) After that, molecular docking was performed by MVD(molegro virtual docker) software Results : The results are identified to have inhibitory activities against novel COVID-19 protease Of these compounds, Ginkgolide A has a stronger bond and high affinity with protease Conclusion : Finally, with due attention to the high effectiveness function of terpenoids, we can conclude that these compounds may be considered as effectire COVID_19 antiprotease drugs
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