eow9ebpm | Knowledge4COVID-19

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?:abstract	There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-CoV-2 in the ferret model. After a high (5 × 10(6) pfu) and medium (5 × 10(4) pfu) dose of virus is delivered, intranasally, viral RNA shedding in the upper respiratory tract (URT) is observed in 6/6 animals, however, only 1/6 ferrets show similar signs after low dose (5 × 10(2) pfu) challenge. Following sequential culls pathological signs of mild multifocal bronchopneumonia in approximately 5–15% of the lung is seen on day 3, in high and medium dosed groups. Ferrets re-challenged, after virus shedding ceased, are fully protected from acute lung pathology. The endpoints of URT viral RNA replication & distinct lung pathology are observed most consistently in the high dose group. This ferret model of SARS-CoV-2 infection presents a mild clinical disease.
?:creator	<https://research.tib.eu/covid-19/entity/Ryan%2C_Kathryn_A.%3B_Bewley%2C_Kevin_R.%3B_Fotheringham%2C_Susan_A.%3B_Slack%2C_Gillian_S.%3B_Brown%2C_Phillip%3B_Hall%2C_Yper%3B_Wand%2C_Nadina_I.%3B_Marriott%2C_Anthony_C.%3B_Cavell%2C_Breeze_E.%3B_Tree%2C_Julia_A.%3B_Allen%2C_Lauren%3B_Aram%2C_Marilyn_J.%3B_Bean%2C_Thomas_J.%3B_Brunt%2C_Emily%3B_Buttigieg%2C_Karen_R.%3B_Carter%2C_Daniel_P.%3B_Cobb%2C_Rebecca%3B_Coombes%2C_Naomi_S.%3B_Findlay-Wilson%2C_Steve_J.%3B_Godwin%2C_Kerry_J.%3B_Gooch%2C_Karen_E.%3B_Gouriet%2C_Jade%3B_Halkerston%2C_Rachel%3B_Harris%2C_Debbie_J.%3B_Hender%2C_Thomas_H.%3B_Humphries%2C_Holly_E.%3B_Hunter%2C_Laura%3B_Ho%2C_Catherine_M._K.%3B_Kennard%2C_Chelsea_L.%3B_Leung%2C_Stephanie%3B_Longet%2C_Stephanie%3B_Ngabo%2C_Didier%3B_Osman%2C_Karen_L.%3B_Paterson%2C_Jemma%3B_Penn%2C_Elizabeth_J.%3B_Pullan%2C_Steven_T.%3B_Rayner%2C_Emma%3B_Skinner%2C_Oliver%3B_Steeds%2C_Kimberley%3B_Taylor%2C_Irene%3B_Tipton%2C_Tom%3B_Thomas%2C_Stephen%3B_Turner%2C_Carrie%3B_Watson%2C_Robert_J.%3B_Wiblin%2C_Nathan_R.%3B_Charlton%2C_Sue%3B_Hallis%2C_Bassam%3B_Hiscox%2C_Julian_A.%3B_Funnell%2C_Simon%3B_Dennis%2C_Mike_J.%3B_Whittaker%2C_Catherine_J.%3B_Catton%2C_Michael_G.%3B_Druce%2C_Julian%3B_Salguero%2C_Francisco_J.%3B_Carroll%2C_Miles_W.>
?:doi	10.1038/s41467-020-20439-y
?:doi	<https://research.tib.eu/covid-19/entity/10.1038/s41467-020-20439-y>
?:journal	Nat_Commun
?:license	cc-by
?:pdf_json_files	document_parses/pdf_json/c8aa1b8e8c857530af675cc786133d5ffb34f925.json; document_parses/pdf_json/5b7871d782a58d263d85e3effadcf5f698762d56.json
?:pmc_json_files	document_parses/pmc_json/PMC7782478.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7782478>
?:pmid	<https://research.tib.eu/covid-19/entity/33398055.0>
?:pmid	33398055.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/c8aa1b8e8c857530af675cc786133d5ffb34f925%3B%205b7871d782a58d263d85e3effadcf5f698762d56>
?:source	Medline; PMC
?:title	Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2021-01-04

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