flmu2jjn

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?:abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19 Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments We show that African green monkeys (AGMs) support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species SARS-CoV-2 was detected in mucosal samples, including rectal swabs, as late as 15 days after exposure Marked inflammation and coagulopathy in blood and tissues were prominent features Transcriptome analysis demonstrated stimulation of interferon and interleukin-6 pathways in bronchoalveolar lavage samples and repression of natural killer cell- and T cell-associated transcripts in peripheral blood Despite a slight waning in antibody titers after primary challenge, enhanced antibody and cellular responses contributed to rapid clearance after re-challenge with an identical strain These data support the utility of AGM for studying COVID-19 pathogenesis and testing medical countermeasures Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments. We show that African green monkeys (AGMs) support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species. SARS-CoV-2 was detected in mucosal samples, including rectal swabs, as late as 15 days after exposure. Marked inflammation and coagulopathy in blood and tissues were prominent features. Transcriptome analysis demonstrated stimulation of interferon and interleukin-6 pathways in bronchoalveolar lavage samples and repression of natural killer cell- and T cell-associated transcripts in peripheral blood. Despite a slight waning in antibody titers after primary challenge, enhanced antibody and cellular responses contributed to rapid clearance after re-challenge with an identical strain. These data support the utility of AGM for studying COVID-19 pathogenesis and testing medical countermeasures.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/flmu2jjn_hasAnnotation_C0021368> <https://research.tib.eu/covid-19/entity/flmu2jjn_hasAnnotation_C0205339> <https://research.tib.eu/covid-19/entity/flmu2jjn_hasAnnotation_C1415932> <https://research.tib.eu/covid-19/entity/flmu2jjn_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Woolsey%2C_C.%3B_Borisevich%2C_V.%3B_Prasad%2C_A._N.%3B_Agans%2C_K._N.%3B_Deer%2C_D._J.%3B_Dobias%2C_N._S.%3B_Heymann%2C_J._C.%3B_Foster%2C_S._L.%3B_Levine%2C_C._B.%3B_Medina%2C_L.%3B_Melody%2C_K.%3B_Geisbert%2C_J._B.%3B_Fenton%2C_K._A.%3B_Geisbert%2C_T._W.%3B_Cross%2C_R._W.> <https://research.tib.eu/covid-19/entity/Woolsey%2C_Courtney%3B_Borisevich%2C_Viktoriya%3B_Prasad%2C_Abhishek_N%3B_Agans%2C_Krystle_N%3B_Deer%2C_Daniel_J%3B_Dobias%2C_Natalie_S%3B_Heymann%2C_John_C%3B_Foster%2C_Stephanie_L%3B_Levine%2C_Corri_B%3B_Medina%2C_Liana%3B_Melody%2C_Kevin%3B_Geisbert%2C_Joan_B%3B_Fenton%2C_Karla_A%3B_Geisbert%2C_Thomas_W%3B_Cross%2C_Robert_W>
?:journal	Nat._immunol Nature_Immunology
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/flmu2jjn_HAS_C1415932_CAUSES_C5203670>
?:source	WHO
?:title	Establishment of an African green monkey model for COVID-19 and protection against re-infection
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1065906 #943912
?:year	2020 2021

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Value

?:abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19 Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments We show that African green monkeys (AGMs) support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species SARS-CoV-2 was detected in mucosal samples, including rectal swabs, as late as 15 days after exposure Marked inflammation and coagulopathy in blood and tissues were prominent features Transcriptome analysis demonstrated stimulation of interferon and interleukin-6 pathways in bronchoalveolar lavage samples and repression of natural killer cell- and T cell-associated transcripts in peripheral blood Despite a slight waning in antibody titers after primary challenge, enhanced antibody and cellular responses contributed to rapid clearance after re-challenge with an identical strain These data support the utility of AGM for studying COVID-19 pathogenesis and testing medical countermeasures
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments. We show that African green monkeys (AGMs) support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species. SARS-CoV-2 was detected in mucosal samples, including rectal swabs, as late as 15 days after exposure. Marked inflammation and coagulopathy in blood and tissues were prominent features. Transcriptome analysis demonstrated stimulation of interferon and interleukin-6 pathways in bronchoalveolar lavage samples and repression of natural killer cell- and T cell-associated transcripts in peripheral blood. Despite a slight waning in antibody titers after primary challenge, enhanced antibody and cellular responses contributed to rapid clearance after re-challenge with an identical strain. These data support the utility of AGM for studying COVID-19 pathogenesis and testing medical countermeasures.

is ?:annotates of