PropertyValue
?:abstract
  • beta-Coronaviruses are a family of positive-strand enveloped RNA viruses that includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Much is known regarding their cellular entry and replication pathways, but their mode of egress remains uncertain Using imaging methodologies and virus-specific reporters, we demonstrate that beta-coronaviruses utilize lysosomal trafficking for egress rather than the biosynthetic secretory pathway more commonly used by other enveloped viruses This unconventional egress is regulated by the Arf-like small GTPase Arl8b and can be blocked by the Rab7 GTPase competitive inhibitor CID1067700 Such non-lytic release of beta-coronaviruses results in lysosome deacidification, inactivation of lysosomal degradation enzymes, and disruption of antigen presentation pathways beta-Coronavirus-induced exploitation of lysosomal organelles for egress provides insights into the cellular and immunological abnormalities observed in patients and suggests new therapeutic modalities
is ?:annotates of
?:creator
?:journal
  • Cell
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • beta-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway
?:type
?:who_covidence_id
  • #915356
?:year
  • 2020

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