fttlfxti

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?:abstract	OBJECTIVE: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity STUDY DESIGN: We conducted a multicenter, retrospective, and prospective study of pediatric patients hospitalized with acute SARS-CoV-2 infections and multisystem inflammatory syndrome in children (MIS-C) at 8 sites in New York, New Jersey, and Connecticut RESULTS: We identified 281 hospitalized patients with SARS-CoV-2 infections and divided them into 3 groups based on clinical features Overall, 143 (51%) had respiratory disease, 69 (25%) had MIS-C, and 69 (25%) had other manifestations including gastrointestinal illness or fever Patients with MIS-C were more likely to identify as non-Hispanic black compared with patients with respiratory disease (35% vs 18%, P = 02) Seven patients (2%) died and 114 (41%) were admitted to the intensive care unit In multivariable analyses, obesity (OR 3 39, 95% CI 1 26-9 10, P = 02) and hypoxia on admission (OR 4 01;95% CI 1 14-14 15;P = 03) were predictive of severe respiratory disease Lower absolute lymphocyte count (OR 8 33 per unit decrease in 109 cells/L, 95% CI 2 32-33 33, P = 001) and greater C-reactive protein (OR 1 06 per unit increase in mg/dL, 95% CI 1 01-1 12, P = 017) were predictive of severe MIS-C Race/ethnicity or socioeconomic status were not predictive of disease severity CONCLUSIONS: We identified variables at the time of hospitalization that may help predict the development of severe SARS-CoV-2 disease manifestations in children and youth These variables may have implications for future prognostic tools that inform hospital admission and clinical management OBJECTIVE: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity. STUDY DESIGN: We conducted a multicenter, retrospective, and prospective study of pediatric patients hospitalized with acute SARS-CoV-2 infections and multisystem inflammatory syndrome in children (MIS-C) at 8 sites in New York, New Jersey, and Connecticut. RESULTS: We identified 281 hospitalized patients with SARS-CoV-2 infections and divided them into 3 groups based on clinical features. Overall, 143 (51%) had respiratory disease, 69 (25%) had MIS-C, and 69 (25%) had other manifestations including gastrointestinal illness or fever. Patients with MIS-C were more likely to identify as non-Hispanic black compared with patients with respiratory disease (35% vs 18%, P = .02). Seven patients (2%) died and 114 (41%) were admitted to the intensive care unit. In multivariable analyses, obesity (OR 3.39, 95% CI 1.26-9.10, P = .02) and hypoxia on admission (OR 4.01; 95% CI 1.14-14.15; P = .03) were predictive of severe respiratory disease. Lower absolute lymphocyte count (OR 8.33 per unit decrease in 109 cells/L, 95% CI 2.32-33.33, P = .001) and greater C-reactive protein (OR 1.06 per unit increase in mg/dL, 95% CI 1.01-1.12, P = .017) were predictive of severe MIS-C. Race/ethnicity or socioeconomic status were not predictive of disease severity. CONCLUSIONS: We identified variables at the time of hospitalization that may help predict the development of severe SARS-CoV-2 disease manifestations in children and youth. These variables may have implications for future prognostic tools that inform hospital admission and clinical management.
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?:creator	<https://research.tib.eu/covid-19/entity/Fernandes%2C_D._M.%3B_Oliveira%2C_C._R.%3B_Guerguis%2C_S.%3B_Eisenberg%2C_R.%3B_Choi%2C_J.%3B_Kim%2C_M.%3B_Abdelhemid%2C_A.%3B_Agha%2C_R.%3B_Agarwal%2C_S.%3B_Aschner%2C_J._L.%3B_Avner%2C_J._R.%3B_Ballance%2C_C.%3B_Bock%2C_J.%3B_Bhavsar%2C_S._M.%3B_Campbell%2C_M.%3B_Clouser%2C_K._N.%3B_Gesner%2C_M.%3B_Goldman%2C_D._L.%3B_Hammerschlag%2C_M._R.%3B_Hymes%2C_S.%3B_Howard%2C_A.%3B_Jung%2C_H._J.%3B_Kohlhoff%2C_S.%3B_Kojaoghlanian%2C_T.%3B_Lewis%2C_R.%3B_Nachman%2C_S.%3B_Naganathan%2C_S.%3B_Paintsil%2C_E.%3B_Pall%2C_H.%3B_Sy%2C_S.%3B_Wadowski%2C_S.%3B_Zirinsky%2C_E.%3B_Cabana%2C_M._D.%3B_Herold%2C_B._C.%3B_Tri-State_Pediatric%2C_Covid-Research_Consortium> <https://research.tib.eu/covid-19/entity/Fernandes%2C_Danielle_M%3B_Oliveira%2C_Carlos_R%3B_Guerguis%2C_Sandra%3B_Eisenberg%2C_Ruth%3B_Choi%2C_Jaeun%3B_Kim%2C_Mimi%3B_Abdelhemid%2C_Ashraf%3B_Agha%2C_Rabia%3B_Agarwal%2C_Saranga%3B_Aschner%2C_Judy_L%3B_Avner%2C_Jeffrey_R%3B_Ballance%2C_Cathleen%3B_Bock%2C_Joshua%3B_Bhavsar%2C_Sejal_M%3B_Campbell%2C_Melissa%3B_Clouser%2C_Katharine_N%3B_Gesner%2C_Matthew%3B_Goldman%2C_David_L%3B_Hammerschlag%2C_Margaret_R%3B_Hymes%2C_Saul%3B_Howard%2C_Ashley%3B_Jung%2C_Hee-Jin%3B_Kohlhoff%2C_Stephan%3B_Kojaoghlanian%2C_Tsoline%3B_Lewis%2C_Rachel%3B_Nachman%2C_Sharon%3B_Naganathan%2C_Srividya%3B_Paintsil%2C_Elijah%3B_Pall%2C_Harpreet%3B_Sy%2C_Sharlene%3B_Wadowski%2C_Stephen%3B_Zirinsky%2C_Elissa%3B_Cabana%2C_Michael_D%3B_Herold%2C_Betsy_C>
?:journal	J._pediatr._(Rio_J.) Journal_of_Pediatrics
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/fttlfxti_HAS_C0006560_PREDISPOSES_C5389369>
?:source	WHO
?:title	Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#922075 #977144
?:year	2020

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?:abstract

OBJECTIVE: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity STUDY DESIGN: We conducted a multicenter, retrospective, and prospective study of pediatric patients hospitalized with acute SARS-CoV-2 infections and multisystem inflammatory syndrome in children (MIS-C) at 8 sites in New York, New Jersey, and Connecticut RESULTS: We identified 281 hospitalized patients with SARS-CoV-2 infections and divided them into 3 groups based on clinical features Overall, 143 (51%) had respiratory disease, 69 (25%) had MIS-C, and 69 (25%) had other manifestations including gastrointestinal illness or fever Patients with MIS-C were more likely to identify as non-Hispanic black compared with patients with respiratory disease (35% vs 18%, P = 02) Seven patients (2%) died and 114 (41%) were admitted to the intensive care unit In multivariable analyses, obesity (OR 3 39, 95% CI 1 26-9 10, P = 02) and hypoxia on admission (OR 4 01;95% CI 1 14-14 15;P = 03) were predictive of severe respiratory disease Lower absolute lymphocyte count (OR 8 33 per unit decrease in 109 cells/L, 95% CI 2 32-33 33, P = 001) and greater C-reactive protein (OR 1 06 per unit increase in mg/dL, 95% CI 1 01-1 12, P = 017) were predictive of severe MIS-C Race/ethnicity or socioeconomic status were not predictive of disease severity CONCLUSIONS: We identified variables at the time of hospitalization that may help predict the development of severe SARS-CoV-2 disease manifestations in children and youth These variables may have implications for future prognostic tools that inform hospital admission and clinical management
OBJECTIVE: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity. STUDY DESIGN: We conducted a multicenter, retrospective, and prospective study of pediatric patients hospitalized with acute SARS-CoV-2 infections and multisystem inflammatory syndrome in children (MIS-C) at 8 sites in New York, New Jersey, and Connecticut. RESULTS: We identified 281 hospitalized patients with SARS-CoV-2 infections and divided them into 3 groups based on clinical features. Overall, 143 (51%) had respiratory disease, 69 (25%) had MIS-C, and 69 (25%) had other manifestations including gastrointestinal illness or fever. Patients with MIS-C were more likely to identify as non-Hispanic black compared with patients with respiratory disease (35% vs 18%, P = .02). Seven patients (2%) died and 114 (41%) were admitted to the intensive care unit. In multivariable analyses, obesity (OR 3.39, 95% CI 1.26-9.10, P = .02) and hypoxia on admission (OR 4.01; 95% CI 1.14-14.15; P = .03) were predictive of severe respiratory disease. Lower absolute lymphocyte count (OR 8.33 per unit decrease in 109 cells/L, 95% CI 2.32-33.33, P = .001) and greater C-reactive protein (OR 1.06 per unit increase in mg/dL, 95% CI 1.01-1.12, P = .017) were predictive of severe MIS-C. Race/ethnicity or socioeconomic status were not predictive of disease severity. CONCLUSIONS: We identified variables at the time of hospitalization that may help predict the development of severe SARS-CoV-2 disease manifestations in children and youth. These variables may have implications for future prognostic tools that inform hospital admission and clinical management.

is ?:annotates of