?:abstract
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Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, including chemosensory and/or sinonasal dysfunction This study utilized the National Library of Medicine\'s PubMed/MEDLINE database to query for articles describing COVID-19, SARS-CoV-2, SARS-CoV-1, MERS-CoV, and other coronaviruses, with any mention of smell, taste, or other chemosensory or sinonasal dysfunction Aggregate analysis demonstrated an incidence of 49 6% (n = 497 of 1002;95% CI, 46 5%-52 7%), 47 9% (n = 480 of 1002;95% CI, 44 8%-51 0%), and 17 9% (n = 880 of 4909;95% CI, 16 9%-19 0%) for smell loss, taste loss, and smell or taste loss, respectively, in patients infected with SARS-CoV-2 Additionally, there were significantly higher incidences of runny nose/rhinorrhea/rhinitis and nasal congestion/obstruction/blockage in other coronaviruses as compared with SARS-CoV-2 (P < 001) Understanding these less well-characterized symptoms may help develop measures for estimating early markers of disease prevalence and/or resolution
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