gq9tq39x

Property	Value
?:abstract	OBJECTIVE To investigate the effect of artificial liver blood purification treatment on the survival of severe/critical patients with COVID-19. METHODS A total of 101 severe and critical patients with SARS-CoV-2 infection were enrolled in this open, case-control, multicentre, prospective study. According to the patients\' and their families\' willingness, they were divided into two groups. One was named the treatment group, in which the patients received artificial liver therapy plus comprehensive treatment, while the other was named the control group, in which the patients received only comprehensive treatment. Clinical data and laboratory examinations, as well as the 28-day mortality rate, were collected and analysed. RESULTS This study involved 101 severe/critical patients with COVID-19, among which 50 were in the treatment group and 51 were in the control group. Baseline data comparisons on average age, sex, pre-treatment morbidity, initial symptoms, vital signs, pneumonia severity index (PSI) score, blood routine examination and biochemistry indices et al. showed no difference between the two groups. Cytokine storm was detected, with a significant increase of serum IL-6 level. The serum IL-6 level decreased from 119.94 pg/mL to 20.49 pg/mL in the treatment group and increased from 40.42 pg/mL to 50.81 pg/mL in the control group (p<0.05), indicating that artificial liver therapy significantly decreased serum IL-6. The median duration of viral nucleic acid persistence was 19 days in the treatment group (ranging from 6-67 days) and 17 days in the control group (ranging from 3-68 days), no significant difference was observed (p=0.36). As of 28-day follow-up,17 patients in the treatment group experienced a median weaning time of 24 days, while 11 patients in the control group experienced a median weaning time of 35 days, with no significant difference between the two groups (p=0.33). The 28-day mortality rates were 16% (8/50) in the treatment group and 50.98% (26/51) in the control group, with a significant difference (z=3.70, p<0.001). CONCLUSION Cytokine storm is a key factor in the intensification of COVID-19 pneumonia. The artificial liver therapy blocks the cytokine storm by clearing inflammatory mediators, thus preventing severe cases from progressing to critically ill stages and markedly reducing short-term mortality.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/gq9tq39x_hasAnnotation_C0231218> <https://research.tib.eu/covid-19/entity/gq9tq39x_hasAnnotation_C0243042> <https://research.tib.eu/covid-19/entity/gq9tq39x_hasAnnotation_C1457887>
?:creator	<https://research.tib.eu/covid-19/entity/Xiahong%2C_Dai%3B_Zhang%2C_Yimin%3B_Liang%2C_Yu%3B_Ying-An%2C_Jiang%3B_Liang%2C_Chen%3B_Ye%2C_Chen%3B_Ming%2C_Li%3B_Chunming%2C_Gao%3B_Jia%2C_Shang%3B_Shulin%2C_Xiang%3B_Yongguo%2C_Li%3B_Jianzhou%2C_Li%3B_Chenliang%2C_Zhou%3B_Xiaoyang%2C_Zhou%3B_Nan%2C_Chen%3B_Yuanchun%2C_Liu%3B_Jing%2C_Liu%3B_Yuanyuan%2C_Zhang%3B_Xiaobei%2C_Chen%3B_Danhua%2C_Zhu%3B_Hainv%2C_Gao%3B_Lingling%2C_Tang%3B_Mengfei%2C_Zhu%3B_Li%2C_Lanjuan>
?:doi	10.1111/aor.13884
?:doi	<https://research.tib.eu/covid-19/entity/10.1111/aor.13884>
?:journal	Artificial_organs
?:license	unk
?:pmid	<https://research.tib.eu/covid-19/entity/33326621>
?:pmid	33326621
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	Medline
?:title	Effect of Artificial Liver Blood Purification Treatment on the Survival of Critical Ill COVID-19 Patients.
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-12-16

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Value

?:abstract

OBJECTIVE To investigate the effect of artificial liver blood purification treatment on the survival of severe/critical patients with COVID-19. METHODS A total of 101 severe and critical patients with SARS-CoV-2 infection were enrolled in this open, case-control, multicentre, prospective study. According to the patients\' and their families\' willingness, they were divided into two groups. One was named the treatment group, in which the patients received artificial liver therapy plus comprehensive treatment, while the other was named the control group, in which the patients received only comprehensive treatment. Clinical data and laboratory examinations, as well as the 28-day mortality rate, were collected and analysed. RESULTS This study involved 101 severe/critical patients with COVID-19, among which 50 were in the treatment group and 51 were in the control group. Baseline data comparisons on average age, sex, pre-treatment morbidity, initial symptoms, vital signs, pneumonia severity index (PSI) score, blood routine examination and biochemistry indices et al. showed no difference between the two groups. Cytokine storm was detected, with a significant increase of serum IL-6 level. The serum IL-6 level decreased from 119.94 pg/mL to 20.49 pg/mL in the treatment group and increased from 40.42 pg/mL to 50.81 pg/mL in the control group (p<0.05), indicating that artificial liver therapy significantly decreased serum IL-6. The median duration of viral nucleic acid persistence was 19 days in the treatment group (ranging from 6-67 days) and 17 days in the control group (ranging from 3-68 days), no significant difference was observed (p=0.36). As of 28-day follow-up,17 patients in the treatment group experienced a median weaning time of 24 days, while 11 patients in the control group experienced a median weaning time of 35 days, with no significant difference between the two groups (p=0.33). The 28-day mortality rates were 16% (8/50) in the treatment group and 50.98% (26/51) in the control group, with a significant difference (z=3.70, p<0.001). CONCLUSION Cytokine storm is a key factor in the intensification of COVID-19 pneumonia. The artificial liver therapy blocks the cytokine storm by clearing inflammatory mediators, thus preventing severe cases from progressing to critically ill stages and markedly reducing short-term mortality.

is ?:annotates of