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Critical cases of coronavirus disease 2019 (COVID-19) are associated with a high risk of mortality It remains unclear why patients with the same critical condition have different outcomes We aimed to explore relevant factors that may affect the prognosis of critical COVID-19 patients Six critical COVID-19 inpatients were included in our study The six patients were divided into two groups based on whether they had a good or poor prognosis We collected peripheral blood samples at admission and the time point of exacerbation to compare differences in the phenotypes and functions of major populations of immune cells between the groups On admission, compared to patients with poor prognoses, those with good prognoses had significantly higher counts of monocytes (P +CD4+CD45RO+CXCR3+ subsets (P +CD11C+HLA-DR+ subset of dendritic cells (P + T cells (P + memory T cells were relatively lower (P < 05) According to our results, the poor prognosis group showed a worse immune response than the good prognosis group at the time of admission and at exacerbation Dysregulation of the immune response affects the outcome of critical COVID-19 patients
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Journal_of_Medical_Virology
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Dysregulation of the immune response affects the outcome of critical COVID-19 patients. (Special issue on new coronavirus (2019-nCoV or SARS-CoV-2) and the outbreak of the respiratory illness (COVID-19): part-VII.)
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