PropertyValue
?:abstract
  • Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.
?:creator
?:doi
  • 10.18632/aging.202422
?:doi
?:journal
  • Aging_(Albany_NY)
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/ccadf0e9fb9f3b41f878b2558323d579a5176a85.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7803547.xml.json
?:pmcid
?:pmid
?:pmid
  • 33361522.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
?:type
?:year
  • 2020-12-27

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