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Antibody surveillance provides essential information for public health officials to work with communities to discuss the spread and impact of COVID-19 in communities. At the state of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the diagnostic testing was limited with many asymptomatic cases. Irrespective of symptom severity, antibodies develop within two to three weeks after disease onset and may persist 6 months or more, antibody surveillance is an important tool for tracking trends in past infections across diverse populations. This study includes adults and children recruited from a statewide sample of past 2014-2020 Survey of the Health of Wisconsin (SHOW) participants. SHOW, an ongoing population-based health examination study including a randomly selected sample of households, partnered with the Wisconsin Department of Health Services and the Wisconsin State Laboratory of Hygiene to conduct longitudinal antibody surveillance using the Abbott Architect SARS-CoV-2 IgG antibody test. WAVEs I and II of three planned WAVES were complete in mid-summer to late fall respectively, WAVE III is planned for early 2021. From WAVE I to WAVE II, crude estimates of seroprevalence in the total study population increased four to five-fold from 1.9% to 7.3%. Within the statewide probability sample, weighted estimates increased from an estimated 1.6% (95% CI:0.6-2.5%) seropositivity to 6.8% (95% CI:4.3-9.4%). Seroprevalence varied by health region in both waves, and significant disparities in smaller population groups were identified. This public health and academic partnership provides critical data for public health response to the pandemic and lays the foundation for future research into longer-term immunity, health impacts and population level disparities.
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?:doi
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10.1101/2020.12.18.20248479
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document_parses/pdf_json/be04d82f08f229a96d370cf90d3a90363a543997.json
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Population Changes in Seroprevalence among a Statewide Sample in the United States
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