huocmspj

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?:abstract	AIMS: We aimed to assess whether expression of whole-blood RNA of sodium proton exchanger 1 (NHE1) and glucose transporter 1 (GLUT1) is associated with COVID-19 infection and outcome in patients presenting to the emergency department with respiratory infections Furthermore, we investigated NHE1 and GLUT1 expression in the myocardium of deceased COVID-19 patients METHODS AND RESULTS: Whole-blood quantitative assessment of NHE1 and GLUT1 RNA was performed using quantitative PCR in patients with respiratory infection upon first contact in the emergency department and subsequently stratified by SARS-CoV-2 infection status Assessment of NHE1 and GLUT1 RNA using PCR was also performed in left ventricular myocardium of deceased COVID-19 patients NHE1 expression is up-regulated in whole blood of patients with COVID-19 compared with other respiratory infections at first medical contact in the emergency department (control: 0 0021 +/- 0 0002, COVID-19: 0 0031 +/- 0 0003, P = 0 01) The ratio of GLUT1 to NHE1 is significantly decreased in the blood of COVID-19 patients who are subsequently intubated and/or die (severe disease) compared with patients with moderate disease (moderate disease: 0 497 +/- 0 083 vs severe disease: 0 294 +/- 0 0336, P = 0 036) This ratio is even further decreased in the myocardium of patients who deceased from COVID-19 in comparison with the myocardium of non-infected donors CONCLUSIONS: NHE1 and GLUT1 may be critically involved in the disease progression of SARS-CoV-2 infection We show here that SARS-CoV-2 infection critically disturbs ion channel expression in the heart A decreased ratio of GLUT1/NHE1 could potentially serve as a biomarker for disease severity in patients with COVID-19 AIMS: We aimed to assess whether expression of whole-blood RNA of sodium proton exchanger 1 (NHE1) and glucose transporter 1 (GLUT1) is associated with COVID-19 infection and outcome in patients presenting to the emergency department with respiratory infections. Furthermore, we investigated NHE1 and GLUT1 expression in the myocardium of deceased COVID-19 patients. METHODS AND RESULTS: Whole-blood quantitative assessment of NHE1 and GLUT1 RNA was performed using quantitative PCR in patients with respiratory infection upon first contact in the emergency department and subsequently stratified by SARS-CoV-2 infection status. Assessment of NHE1 and GLUT1 RNA using PCR was also performed in left ventricular myocardium of deceased COVID-19 patients. NHE1 expression is up-regulated in whole blood of patients with COVID-19 compared with other respiratory infections at first medical contact in the emergency department (control: 0.0021 ± 0.0002, COVID-19: 0.0031 ± 0.0003, P = 0.01). The ratio of GLUT1 to NHE1 is significantly decreased in the blood of COVID-19 patients who are subsequently intubated and/or die (severe disease) compared with patients with moderate disease (moderate disease: 0.497 ± 0.083 vs. severe disease: 0.294 ± 0.0336, P = 0.036). This ratio is even further decreased in the myocardium of patients who deceased from COVID-19 in comparison with the myocardium of non-infected donors. CONCLUSIONS: NHE1 and GLUT1 may be critically involved in the disease progression of SARS-CoV-2 infection. We show here that SARS-CoV-2 infection critically disturbs ion channel expression in the heart. A decreased ratio of GLUT1/NHE1 could potentially serve as a biomarker for disease severity in patients with COVID-19.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/huocmspj_hasAnnotation_C0035668> <https://research.tib.eu/covid-19/entity/huocmspj_hasAnnotation_C0242656> <https://research.tib.eu/covid-19/entity/huocmspj_hasAnnotation_C1335837> <https://research.tib.eu/covid-19/entity/huocmspj_hasAnnotation_C1420232>
?:creator	<https://research.tib.eu/covid-19/entity/Mustroph%2C_J.%3B_Hupf%2C_J.%3B_Hanses%2C_F.%3B_Evert%2C_K.%3B_Baier%2C_M._J.%3B_Evert%2C_M.%3B_Meindl%2C_C.%3B_Wagner%2C_S.%3B_Hubauer%2C_U.%3B_Pietrzyk%2C_G.%3B_Leininger%2C_S.%3B_Staudner%2C_S.%3B_Vogel%2C_M.%3B_Wallner%2C_S.%3B_Zimmermann%2C_M.%3B_Sossalla%2C_S.%3B_Maier%2C_L._S.%3B_Jungbauer%2C_C.> <https://research.tib.eu/covid-19/entity/Mustroph%2C_Julian%3B_Hupf%2C_Julian%3B_Hanses%2C_Frank%3B_Evert%2C_Katja%3B_Baier%2C_Maria_J%3B_Evert%2C_Matthias%3B_Meindl%2C_Christine%3B_Wagner%2C_Stefan%3B_Hubauer%2C_Ute%3B_Pietrzyk%2C_Gabriela%3B_Leininger%2C_Simon%3B_Staudner%2C_Stephan%3B_Vogel%2C_Manuel%3B_Wallner%2C_Stefan%3B_Zimmermann%2C_Markus%3B_Sossalla%2C_Samuel%3B_Maier%2C_Lars_S%3B_Jungbauer%2C_Carsten>
?:journal	ESC_Heart_Fail ESC_heart_failure
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/huocmspj_HAS_C1335837_ASSOCIATED_WITH_C0242656> <https://research.tib.eu/covid-19/entity/huocmspj_HAS_C1420232_ASSOCIATED_WITH_C0242656>
?:source	WHO
?:title	Decreased GLUT1/NHE1 RNA expression in whole blood predicts disease severity in patients with COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1064347 #935057
?:year	2020

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?:abstract

AIMS: We aimed to assess whether expression of whole-blood RNA of sodium proton exchanger 1 (NHE1) and glucose transporter 1 (GLUT1) is associated with COVID-19 infection and outcome in patients presenting to the emergency department with respiratory infections Furthermore, we investigated NHE1 and GLUT1 expression in the myocardium of deceased COVID-19 patients METHODS AND RESULTS: Whole-blood quantitative assessment of NHE1 and GLUT1 RNA was performed using quantitative PCR in patients with respiratory infection upon first contact in the emergency department and subsequently stratified by SARS-CoV-2 infection status Assessment of NHE1 and GLUT1 RNA using PCR was also performed in left ventricular myocardium of deceased COVID-19 patients NHE1 expression is up-regulated in whole blood of patients with COVID-19 compared with other respiratory infections at first medical contact in the emergency department (control: 0 0021 +/- 0 0002, COVID-19: 0 0031 +/- 0 0003, P = 0 01) The ratio of GLUT1 to NHE1 is significantly decreased in the blood of COVID-19 patients who are subsequently intubated and/or die (severe disease) compared with patients with moderate disease (moderate disease: 0 497 +/- 0 083 vs severe disease: 0 294 +/- 0 0336, P = 0 036) This ratio is even further decreased in the myocardium of patients who deceased from COVID-19 in comparison with the myocardium of non-infected donors CONCLUSIONS: NHE1 and GLUT1 may be critically involved in the disease progression of SARS-CoV-2 infection We show here that SARS-CoV-2 infection critically disturbs ion channel expression in the heart A decreased ratio of GLUT1/NHE1 could potentially serve as a biomarker for disease severity in patients with COVID-19
AIMS: We aimed to assess whether expression of whole-blood RNA of sodium proton exchanger 1 (NHE1) and glucose transporter 1 (GLUT1) is associated with COVID-19 infection and outcome in patients presenting to the emergency department with respiratory infections. Furthermore, we investigated NHE1 and GLUT1 expression in the myocardium of deceased COVID-19 patients. METHODS AND RESULTS: Whole-blood quantitative assessment of NHE1 and GLUT1 RNA was performed using quantitative PCR in patients with respiratory infection upon first contact in the emergency department and subsequently stratified by SARS-CoV-2 infection status. Assessment of NHE1 and GLUT1 RNA using PCR was also performed in left ventricular myocardium of deceased COVID-19 patients. NHE1 expression is up-regulated in whole blood of patients with COVID-19 compared with other respiratory infections at first medical contact in the emergency department (control: 0.0021 ± 0.0002, COVID-19: 0.0031 ± 0.0003, P = 0.01). The ratio of GLUT1 to NHE1 is significantly decreased in the blood of COVID-19 patients who are subsequently intubated and/or die (severe disease) compared with patients with moderate disease (moderate disease: 0.497 ± 0.083 vs. severe disease: 0.294 ± 0.0336, P = 0.036). This ratio is even further decreased in the myocardium of patients who deceased from COVID-19 in comparison with the myocardium of non-infected donors. CONCLUSIONS: NHE1 and GLUT1 may be critically involved in the disease progression of SARS-CoV-2 infection. We show here that SARS-CoV-2 infection critically disturbs ion channel expression in the heart. A decreased ratio of GLUT1/NHE1 could potentially serve as a biomarker for disease severity in patients with COVID-19.

is ?:annotates of