PropertyValue
?:abstract
  • Objective: To evaluate the rapid diagnostic value of serum novel coronavirus (2019-nCoV) IgM/IgG detection in COVID-19, aiming to further improve the diagnostic and screening system of COVID-19 Methods: Blood samples were collected from 32 patients with COVID-19 (tested positive for 2019-nCoV nucleic acid by RT-PCR and presented with clinical symptoms) and 34 non-COVID-19 patients (tested negative for 2019-nCoV nucleic acid by RT-PCR and clinically confirmed as non-COVID-19 patients) Colloidal gold-based immunochromatography was used for rapid detection of 2019-nCoV IgM/IgG in these samples The sensitivity and specificity of the test, and the correlation of serum 2019-nCoV IgM/IgG with disease course were analyzed Results: Among the 32 COVID-19 patients, nine tested positive for 2019-nCoV IgM with a positive rate of 28 1% (9/32) and 25 positive for 2019-nCoV IgG with a positive rate of 78 1% (25/32) The total positive rate was 84 4% (27/32) Two of the 34 non-COVID-19 patients tested positive for 2019-nCoV IgG with a positive rate of 5 9% (2/34), while none of them was positive for 2019-nCoV IgM The positive rates of serum IgM were 42 9% (3/7), 30 8% (4/13) and 16 7% (2/12) at 10-20 d, 21-30 d and 31-40 d after the patients developed the symptoms of COVID-19, respectively, which showed a decreasing tread with prolonged disease course The positive rates of serum IgG in COVID-19 patients were 57 1% (4/7), 84 6% (11/13) and 83 3% (10/12) at 10-20 d, 21-30 d and 30-40 d after symptom onset The rate showed an increasing trend with prolonged disease course and reached the peak in about 21-30 d Conclusions: Serum 2019-nCoV IgM/IgG detection (using colloidal gold method) had high sensitivity (84 4%) and strong specificity (94 1%) in the diagnosis of 2019-nCoV infection It had a great value in the diagnosis and screening of COVID-19 and could be used as a valuable complementary method to the COVID-19 diagnostic system due to its advantages of flexibility, rapidity and simplicity
is ?:annotates of
?:creator
?:journal
  • Chinese_Journal_of_Microbiology_and_Immunology_(China)
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Performance of serum 2019-nCoV IgM/IgG detection in the rapid diagnosis of COVID-19
?:type
?:who_covidence_id
  • #883885
?:year
  • 2020

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