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RNA interference (RNAi) represents a novel approach for alternative antiviral therapy However, issues related to RNA delivery and stability have presented serious obstacles for obtaining good therapeutic efficacy Viral vectors are capable of efficient delivery of RNAi as short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA) Efficacy in gene silencing for therapeutic applications against viral diseases has been demonstrated in various animal models Rotavirus (RV) miR-7 can inhibit rotavirus replication by targeting the RV nonstructural protein 5 Viral gene silencing by targeting the RNAi pathway showed efficient suppression of hepatitis B virus replication by adeno-associated virus (AAV)-based delivery of RNAi hepatitis B virus (HBV) cassettes Hepatitis C virus replication has been targeted by short hairpin RNA molecules expressed from lentivirus vectors Potentially, RNAi-based approaches could be suitable for antiviral drugs against COVID-19
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Are Viral Vectors Any Good for RNAi Antiviral Therapy?
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