PropertyValue
?:abstract
  • The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1002/btm2.10202
?:journal
  • Bioeng_Transl_Med
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/e3e6f41c0279366c3c6b1caf20868e1bbc002911.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7744900.xml.json
?:pmcid
?:pmid
?:pmid
  • 33349797.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
?:type
?:year
  • 2020-12-12

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