PropertyValue
?:abstract
  • Inhibitors of the bacterial enzyme dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18) hold promise as antibiotics with a new mechanism of action. Herein we describe the discovery of a new series of indoline sulfonamide DapE inhibitors from a high-throughput screen and the synthesis of a series of analogs. Inhibitory potency was measured by a ninhydrin-based DapE assay recently developed by our group. Molecular docking experiments suggest active site binding with the sulfonamide acting as a zinc-binding group (ZBG).
is ?:annotates of
?:creator
?:doi
  • 10.3390/antibiotics9090595
?:doi
?:journal
  • Antibiotics_(Basel)
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/8abddf5dd40450d7b94d617cccf0e3413b3cc833.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7560015.xml.json
?:pmcid
?:pmid
?:pmid
  • 32933028.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE
?:type
?:year
  • 2020-09-11

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