PropertyValue
?:abstract
  • A novel disease, of unknown origin, causing a deadly pneumonia of human patients was reported in December 2019 in Wuhan, Hubei province of China. Later called COVID-19, it rapidly spread across China and worldwide. Intensive research revealed that the etiological agent of the global COVID-19 pandemic was a novel coronavirus named SARS-CoV-2. The SARS-CoV-2 genome contains typical coronavirus genes but the receptor binding domain (RBD) in the S protein is highly specific. The site for furin-like protease cleavage of the S protein into S1 and S2 subunits is also unique. Further analyses suggested that SARS-CoV-2 is of zoonotic origin. The analysis of the SARS-CoV-2 genome, especially the S gene, shows that natural evolutionary process between a bat-CoV and a pangolin-CoV or other animal coronavirus could have been important in creating SARS-CoV-2, with transmission of novel virus to the human population. On the other hand, new analyses indicate that SARS-CoV-2 is not a recombinant virus. Keywords: COVID-19; SARS-CoV-2; genome; bat coronavirus; pangolin coronavirus.
?:creator
?:doi
  • 10.4149/av_2020_302
?:doi
?:journal
  • Acta_virologica
?:license
  • unk
?:pmid
?:pmid
  • 32985202.0
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • SARS-CoV-2: Zoonotic origin of pandemic coronavirus.
?:type
?:year
  • 2020-09-28

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