PropertyValue
?:abstract
  • We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate Enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not EV-D68 and CVB3. NRP1 recognizes EVA71 through a novel domain on VP3 capsid protein. The principle in the design, engineering and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.
is ?:annotates of
?:creator
?:doi
  • 10.1128/aac.00695-20
?:doi
?:journal
  • Antimicrobial_agents_and_chemotherapy
?:license
  • unk
?:pmid
?:pmid
  • 33139286
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • Medline
?:title
  • Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 infection in vitro.
?:type
?:year
  • 2020-11-02

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