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?:abstract
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Hepatic ischemics and the effect of the hypothermia, ischemia and protecting drugs of the ischemic lesions and reperfusion have been studied. The use of several types of drugs that reduce the deleterious effects of the binomial ischemia-reperfusion, have been turning focus of several experimental studies seeking possible clinical applications. The objective of the present study is partially to evaluate the effects of the deferoxamine on ischemia and reperfusion on the remaining liver after parenchyma ressection of 70%, being evaluated by mitochondrial function Mice was divided in groups: Group HP (n = 8)-submitted the partial hepatectomy (HP) to 70%; Group HPD (n = 4)-submitted the deferoxamine administration (40 mg/kg) and HP to 70%; Group HPI (n = 7)-hepatectomizeted (HP to 70%) and submitted by ischemia (40 minutes); Group HPID (n = 7)-similar to the previous, however previously receiving deferoxamine; Group C (n = 8)- controls, submitted to the simulate operation for HP to 70%. The statistical analysis among the several groups was made by the tests of Kruskal - Wallis and of Mann - Whitney, with level of significância of 5%. Of that it sorts things out, the state III was similar in all the procedures; the state IV: C HPI, C HPID (p 0,05); RCR: HP C, HPD C, HPI C and HPID C (p 0,05); PM: HPD was larger than the other groups (P 0,05). In the animals hepatectomizated the ischemia induced increase of the state IV, with and without deferoxamine. On the other hand the deferoxamine induced increase of the membrane potential in the animals hepatectomizated (HPD) in relation to the hepatectomizated with and without ischemia. There was decrease of the respiratory control ratio in the animals hepatectomizated with and without ischemia.
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