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?:abstract
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The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the selected assays there is a wide diversity in assay performance in different scenarios and when correlated to virus neutralizing antibodies. The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies. The large variety of available serological assays requires proper assay validation before deciding on deployment of assays for specific applications.
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?:doi
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10.1038/s41467-020-17317-y
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document_parses/pdf_json/4cd5ba631bdc68bea3a855a33ab2123d40e71f74.json
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document_parses/pmc_json/PMC7338506.xml.json
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?:title
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An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment
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