jexoz2h0

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?:abstract	AIMS: Within the UK, around 70,000 patients suffer neck of femur (NOF) fractures annually. Patients presenting with this injury are often frail, leading to increased morbidity and a 30-day mortality rate of 6.1%. COVID-19 infection has a broad spectrum of clinical presentations with the elderly, and those with pre-existing comorbidities are at a higher risk of severe respiratory compromise and death. Further increased risk has been observed in the postoperative period. The aim of this study was to assess the impact of COVID-19 infection on the complication and mortality rates of NOF fracture patients. METHODS: All NOF fracture patients presenting between March 2020 and May 2020 were included. Patients were divided into two subgroup: those with or without clinical and/or laboratory diagnosis of COVID-19. Data were collected on patient demographics, pattern of injury, complications, length of stay, and mortality. RESULTS: Overall, 132 patients were included. Of these, 34.8% (n = 46) were diagnosed with COVID-19. Bacterial pneumonia was observed at a significantly higher rate in those patients with COVID-19 (56.5% vs 15.1%; p =< 0.000). Non respiratory complications such as acute kidney injury (30.4% vs 9.3%; p =0.002) and urinary tract infection (10.9% vs 3.5%; p =0.126) were also more common in those patients with COVID-19. Length of stay was increased by a median of 21.5 days in patients diagnosed with COVID-19 (p < 0.000). 30-day mortality was significantly higher in patients with COVID-19 (37.0%) when compared to those without (10.5%; p <0.000). CONCLUSION: This study has shown that patients with a neck of femur fracture have a high rate of mortality and complications such as bacterial pneumonia and acute kidney injury when diagnosed with COVID-19 within the perioperative period. We have demonstrated the high risk of in hospital transmission of COVID-19 and the association between the infection and an increased length of stay for the patients affected. Cite this article: Bone Joint Open 2020;1-11:669–675.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/jexoz2h0_hasAnnotation_C0009566> <https://research.tib.eu/covid-19/entity/jexoz2h0_hasAnnotation_C0015806> <https://research.tib.eu/covid-19/entity/jexoz2h0_hasAnnotation_C0161818> <https://research.tib.eu/covid-19/entity/jexoz2h0_hasAnnotation_C0262414> <https://research.tib.eu/covid-19/entity/jexoz2h0_hasAnnotation_C1825598>
?:creator	<https://research.tib.eu/covid-19/entity/Ward%2C_Alex_E.%3B_Tadross%2C_Daniel%3B_Wells%2C_Fiona%3B_Majkowski%2C_Lawrence%3B_Naveed%2C_Umna%3B_Jeyapalan%2C_Rathan%3B_Partridge%2C_David_G.%3B_Madan%2C_Suvira%3B_Blundell%2C_Chris_M.>
?:doi	<https://research.tib.eu/covid-19/entity/10.1302/2633-1462.111.bjo-2020-0141.r1>
?:doi	10.1302/2633-1462.111.bjo-2020-0141.r1
?:journal	Bone_&_joint_open
?:license	cc-by-nc-nd
?:pdf_json_files	document_parses/pdf_json/17e08fd3b132f1a182a16cb08d3fa811ab637f4c.json
?:pmc_json_files	document_parses/pmc_json/PMC7690756.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7690756>
?:pmid	<https://research.tib.eu/covid-19/entity/33263106.0>
?:pmid	33263106.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/jexoz2h0_HAS_C2744535_AFFECTS_C0009566>
?:sha_id	<https://research.tib.eu/covid-19/entity/17e08fd3b132f1a182a16cb08d3fa811ab637f4c>
?:source	Medline; PMC
?:title	The impact of COVID-19 on morbidity and mortality in neck of femur fracture patients: a prospective case-control cohort study
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-02

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?:abstract

AIMS: Within the UK, around 70,000 patients suffer neck of femur (NOF) fractures annually. Patients presenting with this injury are often frail, leading to increased morbidity and a 30-day mortality rate of 6.1%. COVID-19 infection has a broad spectrum of clinical presentations with the elderly, and those with pre-existing comorbidities are at a higher risk of severe respiratory compromise and death. Further increased risk has been observed in the postoperative period. The aim of this study was to assess the impact of COVID-19 infection on the complication and mortality rates of NOF fracture patients. METHODS: All NOF fracture patients presenting between March 2020 and May 2020 were included. Patients were divided into two subgroup: those with or without clinical and/or laboratory diagnosis of COVID-19. Data were collected on patient demographics, pattern of injury, complications, length of stay, and mortality. RESULTS: Overall, 132 patients were included. Of these, 34.8% (n = 46) were diagnosed with COVID-19. Bacterial pneumonia was observed at a significantly higher rate in those patients with COVID-19 (56.5% vs 15.1%; p =< 0.000). Non respiratory complications such as acute kidney injury (30.4% vs 9.3%; p =0.002) and urinary tract infection (10.9% vs 3.5%; p =0.126) were also more common in those patients with COVID-19. Length of stay was increased by a median of 21.5 days in patients diagnosed with COVID-19 (p < 0.000). 30-day mortality was significantly higher in patients with COVID-19 (37.0%) when compared to those without (10.5%; p <0.000). CONCLUSION: This study has shown that patients with a neck of femur fracture have a high rate of mortality and complications such as bacterial pneumonia and acute kidney injury when diagnosed with COVID-19 within the perioperative period. We have demonstrated the high risk of in hospital transmission of COVID-19 and the association between the infection and an increased length of stay for the patients affected. Cite this article: Bone Joint Open 2020;1-11:669–675.

is ?:annotates of