PropertyValue
?:abstract
  • SARS-CoV-2 infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors associated with COVID-19 coronavirus disease and to design effective therapeutic strategies. In this context, we developed a mathematical model of RAS based on data regarding protein and peptide concentrations; the model was tested on clinical data from healthy normotensive and hypertensive individuals. We used our model to analyze the impact of SARS-CoV-2 infection on RAS, which we modeled through a downregulation of ACE2 as a function of viral load. We also used it to predict the effect of RAS-targeting drugs, such as RAS-blockers, human recombinant ACE2, and angiotensin 1–7 peptide, on COVID-19 patients; the model predicted an improvement of the clinical outcome for some drugs and a worsening for others. Our model and its predictions constitute a valuable framework for in silico testing of hypotheses about the COVID-19 pathogenic mechanisms and the effect of drugs aiming to restore RAS functionality.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.3390/v12121367
?:journal
  • Viruses
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/d243d7692779698097ce96eacd6a49e50b480706.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7760740.xml.json
?:pmcid
?:pmid
?:pmid
  • 33265982.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System
?:type
?:year
  • 2020-11-30

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