PropertyValue
?:abstract
  • Background and objectives The timing of invasive mechanical ventilation (IMV) is controversial in COVID-19 patients with acute respiratory hypoxemia The study aimed to develop a novel predictor called cumulative oxygen deficit (COD) for the risk stratification Methods The study was conducted in four designated hospitals for treating COVID-19 patients in Jingmen, Wuhan, from January to March 2020 COD was defined to account for both the magnitude and duration of hypoxemia A higher value of COD indicated more oxygen deficit The predictive performance of COD was calculated in multivariable Cox regression models Results A number of 111 patients including 80 in the non-IMV group and 31 in the IMV group were included Patients with IMV had substantially lower PaO2 (62 (49, 89) vs 90 5 (68, 125 25) mmHg;p 30 mmHg·day had higher risk of fatality (HR: 3 79, 95% CI [2 57–16 93];p = 0 037), and those with COD > 50 mmHg·day were 10 times more likely to die (HR: 10 45, 95% CI [1 28–85 37];p = 0 029) Conclusions The study developed a novel predictor COD which considered both magnitude and duration of hypoxemia, to assist risk stratification of COVID-19 patients with acute respiratory distress
is ?:annotates of
?:creator
?:journal
  • PeerJ
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Cumulative oxygen deficit is a novel predictor for the timing of invasive mechanical ventilation in COVID-19 patients with respiratory distress
?:type
?:who_covidence_id
  • #948184
?:year
  • 2020

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